Pain management in patients with haemophilia: a European survey

摘要: There are no evidence-based guidelines on pain management in people with haemophilia (PWH), who may suffer acute, disabling from haemarthroses and chronic arthropathic pain. To review evidence to investigate current clinical practice assessment PWH the European Haemophilia Therapy Standardisation Board undertook a literature survey 22 Treatment Centres (HTC), using questionnaire seven scenarios. Consensus was sought PWH. Few studies were identified. The HTCs care for 1678 children (47% severe haemophilia, 84% prophylaxis, 17% arthropathy 8% pain) 5103 adults (44% 40% 67% 35% pain). Analgesics prescribed by 80% of cases (median; range 0-100%) 10% 0-80%) bought over counter. Pain analgesic use assessed when reported patients at check-ups. Only eight centres specific scale and/or have guidelines. Two arrange regular consultations specialists. For acute pain, preferred first-line drug is paracetamol children, or non-steroidal anti-inflammatory drugs (NSAIDs) adults. Children treated NSAIDs, whereas usually receive Cox-2 inhibitors. Second-line therapy heterogeneous. little published guide PWH, varies considerably across Europe. General recommendations needed.