Tumor and inflammation markers in melanoma using tissue microarrays: a validation study.
作者： Trine Ollegaard Jensen , Rikke Riber-Hansen , Henrik Schmidt , Stephen Jacques Hamilton-Dutoit , Torben Steiniche
DOI: 10.1097/CMR.0B013E32834A3899
关键词:
摘要: The importance of tumor immune response is ever more evident in melanoma carcinogenesis. One approach to explore the pathological mechanisms involved such responses, and analyze other prognostic markers melanoma, use tissue microarrays (TMAs). However, TMA technology remains be adequately validated this setting. Protein expression patterns whole slides sections from 34 patients were compared for a number inflammation cell using immunohistochemical stains against CD8 (lymphocytes), CD163 (macrophages), micropthalmia transcription factor, N-cadherin, cell-adhesion molecule, c-kit protein (CD117). Using simplified versions previously published grading systems, agreement between slide ranged 83 96%, 81 97% markers, respectively. We conclude that combined with systems are appropriate analyzing both melanoma.
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