Correlation among metallothionein expression, intratumoural macrophage infiltration and the risk of metastasis in human cutaneous malignant melanoma.

摘要: Background  The formation of metastases and the efficacy systemic therapies in cutaneous malignant melanoma (CMM) depend on characteristics tumour cells host immune response. Aberrant expression metallothionein (MT) has been observed several types cancers with poor prognoses. Objective  To perform an immunohistochemical study primary CMM comparing MT tumours without (n = 23) to that samples haematogenous examine correlation between staining immunological markers relevant progression. Methods  labelling different sections was analysed using tissue microarrays for evaluation suitability this method future studies. Results  Our results suggest overexpression is significantly more frequent (P = 0.018) independent Breslow thickness (R = 0.102, P = 0.501). Interestingly, correlated presence tumour-infiltrating CD68+ macrophages (P = 0.003), a known predictive factor progression, thereby suggesting role development defective Furthermore, CD163+ infiltrating metastasis (P < 0.001), whereas CD1a+ dendritic surrounding associated lower risk spread (P = 0.003). Conclusion  demonstrate may represent suitable prognostic can characterize metastasising ability tumour-promoting