Long-term impact of young age at diagnosis on treatment outcome and patterns of failure in patients with ductal carcinoma in situ treated with breast-conserving therapy.

摘要: We reviewed our institution's long-term experience treating patients diagnosed with ductal carcinoma in situ (DCIS) of the breast breast-conserving therapy (BCT) to determine impact patient age on outcome over time. All DCIS cases receiving BCT between 1980 and 1993 were reviewed. Patient demographics (including <45) pathologic factors analyzed for effect outcomes including ipsilateral tumor recurrence (IBTR) survival. included limited surgery (excisional biopsy or lumpectomy) followed by radiotherapy whole (median whole-breast dose: 50 Gy, median bed 60.4 Gy). One hundred forty-five evaluated; follow-up was 19.3 years. Twenty-five developed an IBTR, 5-, 10-, 15-, 20-year actuarial rates 9.9%, 12.2%, 13.7%, 17.5%, respectively. The 10-year rate 23.3% (<45 years) versus 9.1% (≥ 45 (p = 0.05). Younger more frequently invasive recurrences (20-year rates: 20.4% 12.8%, p 0.22) true recurrences/marginal misses index lesion (23.3% 9.7%, 0.04) lower contralateral cancer (0.0% 0.0% 12.0% 20.5%, < 0.01, at 10 20 years, respectively). Young women under have a greater risk local different patterns failure following BCT, which is most notable within years diagnosis.