Cancerization of Lobules and Atypical Ductal Hyperplasia Adjacent to Ductal Carcinoma In Situ of the Breast: Significance for Breast-Conserving Therapy

摘要: Recurrent carcinoma develops in approximately 10% of patients with ductal situ (DCIS) the breast treated local excision and radiation therapy. Cancerization lobules (COL) atypical hyperplasia (ADH)frequently occur at edge DCIS. We postulated that recurrent is associated ADH or COL near DCIS margin, amount left may be too large for eradication by To identify histologic features recurrence, we retrospectively studied specimens 94 radiation. analyzed rim tissue final margin COL, ADH, During a median follow-up 78 months, recurrence developed 9 patients. was recurrence; strongest relationship recurrences same site as lumpectomy bed. significantly low-grade group; high-grade group. Other were not outcome. believe composed cells identified those should considered part lesion. inadequately excised if are margin.