Impact of young age on outcome in patients with ductal carcinoma-in-situ treated with breast-conserving therapy.
作者： Frank A. Vicini , Larry L. Kestin , Neal S. Goldstein , Peter Y. Chen , Jane Pettinga
DOI: 10.1200/JCO.2000.18.2.296
关键词: Surgery 、 Index Lesion 、 Carcinoma 、 Ductal carcinoma 、 Mastectomy 、 Biopsy 、 Radiation therapy 、 Medicine 、 Retrospective cohort study 、 Carcinoma in situ
摘要: PURPOSE: We reviewed our institution’s experience treating patients with ductal carcinoma-in-situ (DCIS) breast-conserving therapy (BCT) to determine the impact of patient age on outcome. PATIENTS AND METHODS: From 1980 1993, 146 were treated BCT for DCIS. All underwent excisional biopsy, and 64% re-excision. received whole-breast irradiation a median dose 45 Gy. Ninety-four percent boost tumor bed, total 60.4 slides every by one pathologist. The follow-up period was 7.2 years. RESULTS: Seventeen developed an ipsilateral local recurrence, 5- 10-year actuarial rates 10.2% 12.4%, respectively. rate failure 26.1% in younger than years versus 8.6% older (P = .03). On multivariate analysis, young independently associated recurrence index lesion (true recurre...
sci-hub.se 参考文章(32)
Neal S. Goldstein, Mario Lacerna, Frank Vicini, Cancerization of Lobules and Atypical Ductal Hyperplasia Adjacent to Ductal Carcinoma In Situ of the Breast: Significance for Breast-Conserving Therapy American Journal of Clinical Pathology. ,vol. 110, pp. 357- 367 ,(1998) , 10.1093/AJCP/110.3.357
A Fourquet, M McNeese, R Amalric, A Recht, B McCormick, B A Bornstein, M E Taylor, R R Kuske, D J Schultz, L J Solin, B G Haffty, W Barrett, J M Kurtz, I T Yeh, B L Fowble, Mammographically detected, clinically occult ductal carcinoma in situ treated with breast-conserving surgery and definitive breast irradiation. The cancer journal from Scientific American. ,vol. 2, pp. 158- 165 ,(1996)
Thomas J. Anderson, David L. Page, Diagnostic Histopathology of the Breast ,(1988)
David R. Cox, Regression Models and Life-Tables Springer Series in Statistics. ,vol. 34, pp. 527- 541 ,(1992) , 10.1007/978-1-4612-4380-9_37
L J Solin, J Kurtz, A Fourquet, R Amalric, A Recht, B A Bornstein, R Kuske, M Taylor, W Barrett, B Fowble, B Haffty, D J Schultz, I T Yeh, B McCormick, M McNeese, Fifteen-year results of breast-conserving surgery and definitive breast irradiation for the treatment of ductal carcinoma in situ of the breast. Journal of Clinical Oncology. ,vol. 14, pp. 754- 763 ,(1996) , 10.1200/JCO.1996.14.3.754
B Fisher, J Dignam, N Wolmark, E Mamounas, J Costantino, W Poller, E R Fisher, D L Wickerham, M Deutsch, R Margolese, N Dimitrov, M Kavanah, Lumpectomy and radiation therapy for the treatment of intraductal breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-17. Journal of Clinical Oncology. ,vol. 16, pp. 441- 452 ,(1998) , 10.1200/JCO.1998.16.2.441
M J Silverstein, M D Lagios, S Martino, B S Lewinsky, P H Craig, P J Beron, P Gamagami, J R Waisman, Outcome after invasive local recurrence in patients with ductal carcinoma in situ of the breast. Journal of Clinical Oncology. ,vol. 16, pp. 1367- 1373 ,(1998) , 10.1200/JCO.1998.16.4.1367
A J Nixon, D Neuberg, D F Hayes, R Gelman, J L Connolly, S Schnitt, A Abner, A Recht, F Vicini, J R Harris, Relationship of patient age to pathologic features of the tumor and prognosis for patients with stage I or II breast cancer. Journal of Clinical Oncology. ,vol. 12, pp. 888- 894 ,(1994) , 10.1200/JCO.1994.12.5.888
FRANK A. VICINI, TIMOTHY J. EBERLEIN, JAMES L. CONNOLLY, ABRAM RECHT, ANTHONY ABNER, STUART J. SCHNITT, WILLIAM SILEN, JAY R. HARRIS, The optimal extent of resection for patients with stages I or II breast cancer treated with conservative surgery and radiotherapy. Annals of Surgery. ,vol. 214, pp. 200- 205 ,(1991) , 10.1097/00000658-199109000-00002
Frank A. Vicini, Mario D. Lacerna, Neal S. Goldstein, Eric M. Horwitz, Carl F. Dmuchowski, Julia R. White, Gregory S. Gustafson, John A. Ingold, Alvaro A. Martinez, Ductal carcinoma in situ detected in the mammographic era: an analysis of clinical, pathologic, and treatment-related factors affecting outcome with breast-conserving therapy. International Journal of Radiation Oncology Biology Physics. ,vol. 39, pp. 627- 635 ,(1997) , 10.1016/S0360-3016(97)00314-3