Differences in the pathologic features of ductal carcinoma in situ of the breast based on patient age

摘要: rence. METHODS. Excised specimens from 177 breasts of 172 patients with DCIS treated BCT were studied. All slides all reviewed. Patients divided into 3 age groups: those , 45 years, ages 45‐59 and $ 60 years. The histologic features that quantified included most common highest nuclear grades, architectural pattern, amount central necrosis (quartiles), calcifications, DCIS, number terminal duct lobular units (TDLUs) cancerization lobules (COL) within 0.42 cm the margin, margin status, size volume excision specimens. RESULTS. years at time diagnosis more frequently had higher grade (highest Grade 3: 69%, 60%, 39%; P 5 0.003), respectively (72%, 62%, 44%; 0.01), respectively. Although not statistically significant, younger tended to have comedo subtype often (31%, 23%, 19%; 0.35), Younger also smaller initial biopsy specimen maximum dimensions (4.3 cm, 5.2 5.7 cm; 0.004), respectively, close or positive margins (89%, 61%, 64%; 0.03), TDLUs COL in 0.42-cm rim tissue adjacent (5.2, 3.6, 1.9; 0.23), No other including when classified as . 50% 75% ducts, calcifications pattern involvement, examined, mean ducts near found occur patients. CONCLUSIONS. may an increased risk local recurrence due volumes, a greater proportion high necrosis. Cancer 2000;88: 2553‐ 60. © 2000 American Society.