Claudin 1 in Breast Tumorigenesis: Revelation of a Possible Novel “Claudin High” Subset of Breast Cancers

摘要: Claudins are the major component of tight junctions in epithelial cells and as such play a key role polarized location ion channels, receptors, enzymes to different membrane domains. In that regard, claudins necessary for harmonious development functional epithelium. Moreover, defective have been associated with neoplastic phenotype cells. Breakdown cell-cell interactions deregulation expression junctional proteins therefore believed be steps invasion metastasis. Several studies suggest participants breast tumorigenesis. this paper, we discuss recent advances our understanding potential claudin 1 cancer. We also significance subset estrogen receptor negative cancers which express “high” levels protein. propose functions both tumor suppressor well enhancer/facilitator