摘要: New animal models of peripheral nerve injury have facilitated our understanding neuropathic pain mechanisms. Nerve increases expression and redistribution newly discovered sodium channels from sensory neuron somata to the site; accumulation at both loci contributes spontaneous ectopic discharge. Large myelinated neurons begin express nociceptive substances, their central terminals sprout into regions dorsal horn. Descending facilitation brain stem horn also in setting injury. These other mechanisms drive various pathologic states sensitization associated with distinct clinical symptoms, such as touch-evoked pain.
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BK Taylor, MA Peterson, AI Basbaum, Persistent cardiovascular and behavioral nociceptive responses to subcutaneous formalin require peripheral nerve input The Journal of Neuroscience. ,vol. 15, pp. 7575- 7584 ,(1995) , 10.1523/JNEUROSCI.15-11-07575.1995
Theodore R. Cummins, Sulayman D. Dib-Hajj, Joel A. Black, Stephen G. Waxman, Sodium channels and the molecular pathophysiology of pain. Progress in Brain Research. ,vol. 129, pp. 3- 19 ,(2000) , 10.1016/S0079-6123(00)29002-X
F.A. Lenz, J.-I. Lee, I.M. Garonzik, L.H. Rowland, P.M. Dougherty, S.E. Hua, Plasticity of pain-related neuronal activity in the human thalamus. Progress in Brain Research. ,vol. 129, pp. 259- 273 ,(2000) , 10.1016/S0079-6123(00)29019-5
W. Jänig, J.D. Levine, M. Michaelis, Chapter 10. Interactions of sympathetic and primary afferent neurons following nerve injury and tissue trauma Progress in Brain Research. ,vol. 113, pp. 161- 184 ,(1996) , 10.1016/S0079-6123(08)61087-0
Armen N Akopian, Veronika Souslova, Steven England, Kenji Okuse, Nobukuni Ogata, Jan Ure, Andrew Smith, Bradley J Kerr, Steven B McMahon, Sue Boyce, Ray Hill, Louise C Stanfa, Anthony H Dickenson, John N Wood, None, The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways Nature Neuroscience. ,vol. 2, pp. 541- 548 ,(1999) , 10.1038/9195
Anthony H. Dickenson, Balances between excitatory and inhibitory events in the spinal cord and chronic pain. Progress in Brain Research. ,vol. 110, pp. 225- 231 ,(1996) , 10.1016/S0079-6123(08)62577-7
Sanja D. Novakovic, Elda Tzoumaka, Joseph G. McGivern, Miki Haraguchi, Lakshmi Sangameswaran, Kathleen R. Gogas, Richard M. Eglen, John C. Hunter, Distribution of the Tetrodotoxin-Resistant Sodium Channel PN3 in Rat Sensory Neurons in Normal and Neuropathic Conditions The Journal of Neuroscience. ,vol. 18, pp. 2174- 2187 ,(1998) , 10.1523/JNEUROSCI.18-06-02174.1998
Martin Michaelis, Xianguo Liu, Wilfrid Jänig, Axotomized and Intact Muscle Afferents But No Skin Afferents Develop Ongoing Discharges of Dorsal Root Ganglion Origin after Peripheral Nerve Lesion The Journal of Neuroscience. ,vol. 20, pp. 2742- 2748 ,(2000) , 10.1523/JNEUROSCI.20-07-02742.2000
K Noguchi, Y Kawai, T Fukuoka, E Senba, K Miki, Substance P induced by peripheral nerve injury in primary afferent sensory neurons and its effect on dorsal column nucleus neurons The Journal of Neuroscience. ,vol. 15, pp. 7633- 7643 ,(1995) , 10.1523/JNEUROSCI.15-11-07633.1995
K. C. Kajander, G. J. Bennett, Onset of a painful peripheral neuropathy in rat: a partial and differential deafferentation and spontaneous discharge in A beta and A delta primary afferent neurons Journal of Neurophysiology. ,vol. 68, pp. 734- 744 ,(1992) , 10.1152/JN.1992.68.3.734