作者: John E. Gerich , Mara Lorenzi , Satoshi Hane , Gail Gustafson , Roger Guillemin
DOI: 10.1016/0026-0495(75)90018-9
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摘要: Abstract To study the role of glucagon in human glucose homeostasis, experimental deficiency was produced by infusing somatostatin (i.v. 250 μg bolus, followed infusion 500 μg/hr) six normal subjects and two hypophysectomized patients—an insulin-dependent diabetic a nondiabetic. In subjects, lowered plasma from mean (± SE) basal level 85 ± 15 to 33 10 pg/ml, p 90 2 73 3 mg 100 ml ,