Evidence for a physiologic role of pancreatic glucagon in human glucose homeostasis: Studies with somatostatin

作者: John E. Gerich , Mara Lorenzi , Satoshi Hane , Gail Gustafson , Roger Guillemin

DOI: 10.1016/0026-0495(75)90018-9

关键词:

摘要: Abstract To study the role of glucagon in human glucose homeostasis, experimental deficiency was produced by infusing somatostatin (i.v. 250 μg bolus, followed infusion 500 μg/hr) six normal subjects and two hypophysectomized patients—an insulin-dependent diabetic a nondiabetic. In subjects, lowered plasma from mean (± SE) basal level 85 ± 15 to 33 10 pg/ml, p 90 2 73 3 mg 100 ml ,

参考文章(26)
Walter A. Muller, Gerald R. Faloona, Roger H. Unger, The influence of the antecedent diet upon glucagon and insulin secretion. The New England Journal of Medicine. ,vol. 285, pp. 1450- 1454 ,(1971) , 10.1056/NEJM197112232852603
Arthur Grollman, William E. McCaleb, Fred N. White, Glucagon deficiency as a cause of hypoglycemia Metabolism. ,vol. 13, pp. 686- 690 ,(1964) , 10.1016/0026-0495(64)90014-9
JOHN E. GERICH, VICTOR SCHNEIDER, STEPHEN E. DIPPE, MAURICE LANGLOIS, CLAUDIO NOACCO, JOHN H. KARAM, PETER H. FORSHAM, Characterization of the Glucagon Response to Hypoglycemia in Man The Journal of Clinical Endocrinology and Metabolism. ,vol. 38, pp. 77- 82 ,(1974) , 10.1210/JCEM-38-1-77
Sigfrid Laurell, Gunnar Tibbling, Colorimetric micro-determination of free fatty acids in plasma Clinica Chimica Acta. ,vol. 16, pp. 57- 62 ,(1967) , 10.1016/0009-8981(67)90269-0
E. Aguilar-Parada, A. M. Eisentraut, R. H. Unger, Effects of Starvation on Plasma Pancreatic Glucagon in Normal Man Diabetes. ,vol. 18, pp. 717- 723 ,(1969) , 10.2337/DIAB.18.11.717
D. J. Koerker, W. Ruch, E. Chideckel, J. Palmer, C. J. Goodner, J. Ensinck, C. C. Gale, Somatostatin: Hypothalamic Inhibitor of the Endocrine Pancreas Science. ,vol. 184, pp. 482- 484 ,(1974) , 10.1126/SCIENCE.184.4135.482
Joseph E. Sokal, Glucagon?An essential hormone The American Journal of Medicine. ,vol. 41, pp. 331- 341 ,(1966) , 10.1016/0002-9343(66)90079-9
Samuel S. C. Yen, Teresa M. Siler, Gary W. De Vane, Effect of Somatostatin in Patients with Acromegaly New England Journal of Medicine. ,vol. 290, pp. 935- 938 ,(1974) , 10.1056/NEJM197404252901704
R. Burgus, N. Ling, M. Butcher, R. Guillemin, Primary Structure of Somatostatin, A Hypothalamic Peptide That Inhibits the Secretion of Pituitary Growth Hormone Proceedings of the National Academy of Sciences of the United States of America. ,vol. 70, pp. 684- 688 ,(1973) , 10.1073/PNAS.70.3.684