Assessing vehicle effects on skin absorption of non-volatile compounds using membrane-coated fiber arrays.
作者： Daniela Karadzovska , Jim Riviere
DOI: 10.3109/15569527.2013.781617
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摘要: AbstractContext: The membrane-coated fiber (MCF) array technique was previously demonstrated to be a rapid, quantitative assessment of the percutaneous absorption volatile compounds, capable studying chemical mixtures and their synergistic effects. In particular, three commercially available coatings (polydimethylsiloxane, polyacrylate carbowax) were shown representative molecular interactions relevant skin absorption.Objective: This study evaluated potential use these fibers as high throughput screening approach for topical formulations. More specifically, MCFs ability predict permeability caffeine (CF), cortisone (CT), mannitol (MN) salicylic acid (SA) applied in water or ethanol unsaturated and/or saturated concentrations, using an additional extraction step obtain analytes appropriate liquid chromatography.Methods: Compound from donor solution carried out by immersion set period ...
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