Surfactant Effects on Skin Absorption of Model Organic Chemicals: Implications for Dermal Risk Assessment Studies

摘要: Occupational and environmental exposures to chemicals are major potential routes of exposure for direct skin toxicity systemic absorption. The majority these complex mixtures, yet most experimental studies assess topical chemical absorption conducted neat or in simple aqueous vehicles. A component many industrial mixtures is surfactants that solubilize ingredients stabilize oily components when present purpose this series experiments was use two well-developed techniques how solution interactions a pure nonbiological vitro system (membrane coated fibers, MCF) compare those seen viable ex vivo biological preparation (isolated perfused porcine flap, IPPSF). Two widely encountered anionic surfactants, sodium lauryl sulfate (SLS) linear alkylbenzene sulfonate (LAS), were studied 10% solutions. rank orders were: water: pentachlorophenol (PCP) > 4-nitrophenol (PNP) parathion fenthion simazine propazine; SLS: PNP PCP LAS: propazine. For all penetrants, greater SLS compared LAS finding consistent with smaller micelle sizes SLS. low-water-solubility compounds, from solutions nearly every case. inert three-fiber MCF array predicted absorptive fluxes the IPPSF, suggesting lack any effects on skin.