Gene Therapy for Gliomas: Molecular Targets, Adenoviral Vectors, and Oncolytic Adenoviruses

摘要: Currently, most of the approved clinical gene therapy protocols involve cancer patients and several therapies are designed to treat brain tumors. Two factors promoting use for gliomas failure toxicity conventional identification genetic abnormalities that contribute malignancy gliomas. During malignant progression astrocitic tumors tumor suppressor genes inactivated, numerous growth oncogenes overexpressed progressively. Thus, theoretically, could be treated by targeting their fundamental molecular defects, provided gene-drug can delivered a sufficient number cells. However, strategies have not been abundantly successful clinically, in part because delivery systems still imperfect. In first this brief review we will discuss common targets second part, evolution adenoviruses as vehicles. addition, examine role recombinant mutant oncolytic anticancer tools. From results date it is clear quite promising but more critical research required, mainly vector field, if achieve true potential ameliorating with