Nortriptyline in Depressed Patients With Left Ventricular Impairment

摘要: Previous studies of the effect tricyclic antidepressants on left ventricular function in depressed patients with moderate to severe impairment have focused primarily imipramine hydrochloride. In a prior study, we found that although had no ejection fraction as measured by first-pass radionuclide angiography, treatment could not be tolerated 50% because intolerable drug-induced orthostatic hypotension. Nortriptyline hydrochloride is an effective antidepressant that, without heart disease, causes significantly less hypotension than imipramine. To see if this advantage safely extended congestive failure, nortriptyline and blood pressure 21 impairment. Ejection was unchanged treatment, developed only one (5%) patients. emerges relatively safe for depression ( JAMA 1986;256:3253-3257)