Tricyclic Antidepressants in Depressed Patients With Cardiac Conduction Disease
作者： Steven P. Roose
DOI: 10.1001/ARCHPSYC.1987.01800150093011
关键词:
摘要: • The observation that fatalities from tricyclic antidepressant (TCA) overdose are associated with heart block and/or arrhythmias has led to concern about the cardiovascular effects of TCAs. Contrary expectations, studies have shown TCAs be relatively safe in patients without disease. However, it is unclear whether these drugs also This prospective study compared risk complication at therapeutic plasma concentrations 196 depressed patients, 155 normal electrocardiograms and 41 either prolonged PR interval bundle-branch block. prevalence second-degree atrioventricular was significantly greater preexisting (9%) than (0.7%). Orthostatic hypotension occurred more frequently imipramine nortriptyline,
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