The syn3 strain HSZP of herpes simplex virus type 1 (HSV1) is not pathogenic for mice and shows limited neural spread

摘要: Abstract Strain HSZP of the herpes simplex virus type 1 (HSV-1) forms large giant cells in vitro. This property was found associated with a mutation that alters codon CGC (in strain KOS or 17 sequence) to CAC sequence), changing amino acid 857 from arginine histidine cytoplasmic domain glycoprotein B (gB) polypeptide chain. Giant cell formation by ANGpath attributed GCC and sequences) GTC 854 same (syn 3 ) region gB molecule. In contrast virus, which is pathogenic (1 LD 50 4 PFU) for adult DBA/2 mice after peripheral inoculation, never be lethal mice. Whereas ANGpath-infected survived acute infection frequently (79%) developed latency regional sensory ganglion (as proved reactivation during explantation), latent reactivated culture at considerably reduced rate (21%). Only 10-day-old were sensitive infection. these, spread site administration mainly hematogenous route. The neural suckling manifested involvement vegetative neurons wall small intestine retroperitoneal ganglia. We conclude HSZP, polykaryocyte-forming syn II, shows limited neuroinvasity administration.