Herpes Simplex Virus Type 1 Targets the MHC Class II Processing Pathway for Immune Evasion

摘要: HSV type 1 (HSV-1) has evolved numerous strategies for modifying immune responses that protect against infection. Important targets of HSV-1 infection are the MHC-encoded peptide receptors. Previous studies have shown a helper T cell response and Ab production play important roles in controlling The reduced capacity infected B cells to stimulate CD4 + is beneficial evade defenses. We investigated impact on MHCII processing pathway, which critical generate help. molecular coplayers MHC class II processing, HLA-DR (DR), HLA-DM (DM), invariant chain (Ii). strongly reduces expression Ii, impairs formation SDS-resistant DR-peptide complexes. Residual activity pathway diminished by viral envelope glycoprotein (gB). Binding gB DR competes with binding Ii. In addition, we found associated DM molecules. Both, gB-associated heterodimers exported from endoplasmic reticulum, as indicated carbohydrate maturation. Evaluation DR, DM, subcellular localization revealed abundant changes intracellular distribution. DR-gB complexes localized vesicles restrained surface expression.