摘要: Mounting an immune response against foreign, extracellular material requires that this be internalized by antigen presenting cells, processed to peptide fragments and then displayed on the cell surface for recognition T receptor helper cells. Such peptides, derived from antigens are generally presented cells in association with Major Histocompatibility Complex (MHC) class II molecules. Recent work has identified subcompartments of endosomal/lysosomal system appear important sites generation peptide-MHC complexes. These so-called MHC compartments receive antigenic endosomes lysosomes load them onto From these compartments, peptide-loaded molecules transported plasma membrane, where they can trigger bearing appropriate receptors. This review summarizes recent characterizing as specialized organelles pathway. Interestingly, share many features common present a wide variety quite different functions. Modifying endocytic pathway serve needs may mechanism which allows very types carry out their disparate
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