Toxicological Assessment of Refined Naphthenic Acids in a Repeated Dose/Developmental Toxicity Screening Test

摘要: Naphthenic acids (NAs) are primarily cycloaliphatic carboxylic with 10 to 16 carbons. To characterize the potential of refined NAs (>70% purity) cause reproductive and/or developmental effects, Sprague-Dawley rats (12/group) were given oral doses 100, 300, or 900 mg/kg/d, beginning 14 days prior mating, then an additional for males through lactation day 3 females (up 53 days) in a repeated dose/reproductive toxicity test (Organization Economic Cooperation and Development [OECD] 422). Potential mutagenic effects assessed using Salmonella (OECD 471) vivo micronucleus tests 474) bone marrow taken from treated animals screening study described previously. Systemic included reduced terminal body weights, increased liver changes number blood cell parameters. The overall no effect level all target organ was 100 mg/kg/d. In reproductive/developmental assessment, there significant reduc...