Molecular Pathology of Colorectal Cancer: From Phenotype to Genotype
作者： M. Dietel
DOI: 10.1007/978-3-642-71967-7_1
关键词:
摘要: In the West, colorectal cancer is second most common in males and third among females, with about 180 000 new cases being diagnosed per year Western Europe. The overall 5-year mortality rate 50–60% after complete tumor removal (R0), whereas it very poor R1/2 resections. Once has metastazised, almost all therapeutic approaches — chemotherapy cytostatic drugs, immunotherapy monoclonal antibodies directed to surface (glyco-)proteins of cells, gene therapy transduction genes stimulate antitumor inflammation or reconstitute mutations, several others have proved be limited efficacy.
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