Prognostic value of p53 overexpression and c-Ki-ras gene mutations in colorectal cancer

摘要: Abstract Background: Mutations in Ki- ras codon 12 and the p53 gene are common abnormalities colorectal cancer. The occurrence of overexpression and/or mutations were analyzed 100 adenomas to determine if they related patient survival. Methods: was identified by immunohistochemistry, detected using polymerase chain reaction a restriction enzyme digestion method. Results: 45% tumors, with higher frequency DNA aneuploid left-sided tumors than diploid right-sided tumors. 24% carcinomas. Individually, or not prognostic indicators However, statistically significant difference survival when these two oncogenic together. median patients whose contained both less half that either alteration alone without abnormality. Conclusions: Screening for multiple genetic cancers excised at surgery may prove be useful tool determining prognosis.