New Insights from Elucidating the Role of LMP1 in Nasopharyngeal Carcinoma

摘要: Latent membrane protein 1 (LMP1) is an Epstein-Barr virus (EBV) oncogenic that has no intrinsic enzymatic activity or sequence homology to cellular viral proteins. The potential of LMP1 been ascribed pleiotropic signaling properties initiated through protein-protein interactions in cytosolic compartments, but the effects extend nuclear and extracellular processes. Although one latent genes required for EBV-immortalization B cells, biology pathogenesis epithelial cancer nasopharyngeal carcinoma (NPC) more complex. NPC prevalent specific regions world with high incidence southeast China. epidemiology time interval from seroconversion onset adults would suggest involvement multiple risk factors complement establishment a persistent EBV infection. contribution polarized epithelia only recently begun be elucidated. Furthermore, gene emerged as most divergent sequences genome. This review will discuss significance recent advances research elucidating function cells lessons could learned mining diversity.