Tear film inflammatory mediators during continuous wear of contact lenses and corneal refractive therapy

摘要: Objectives To study changes in tear film inflammatory mediators following continuous wear of silicone-hydrogel lenses and corneal refractive therapy with reverse geometry contact lenses. Design A prospective, case–control study. Methods Twenty-eight subjects had worn on a 30-night basis. Thirty-two an overnight matched control were also recruited. Tear samples obtained 12 months after initial fitting assayed using ELISA for cytokines (interleukin (IL)-6 IL-8), matrix metalloproteinase 9 (MMP-9) epidermal growth factor (EGF). Results EGF was significantly increased both interventions. IL-6, IL-8 MMP-9 only therapy. The response the patients found to be associated degree myopia corrected presence staining. Moreover, level corneal-pigmented arc group. Conclusions This research showed long-term levels markers wearing when compared or no lens wear.