摘要: Despite improved knowledge and advanced treatments of gliomas, the overall survival rate for glioma patients remains low. Gliomas comprise significant cell heterogeneity that contains a large number multidrug resistant (MDR) phenotypes cancer stem cells (CSCs), combination may contribute to resistance treatment. This article reviews MDR related genes, major-vault protein (MVP), anti-apoptotic (Bcl-2) molecular mechanisms chemoresistance, in addition upregulated present CSCs has recently been identified gliomas. Moreover, future potential therapies modulate are also reviewed. An understanding lead combined treatment, targeting both their protective leading eventually attractive strategies treatment
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