“Low-Risk” Prediction Rule for Pediatric Oncology Patients Presenting With Fever and Neutropenia

摘要: PURPOSE: To prospectively derive and validate a clinical prediction rule to allow more tailored approach the management of pediatric oncology outpatients presenting with fever neutropenia. PATIENTS AND METHODS: The was derived over 1-year period then validated following 8 months in new set neutropenia episodes. Patients were excluded if they presented comorbidity or an abnormal chest x-ray (CXR). RESULTS: Significant bacterial infection (SBI; defined as any blood urine culture positive for bacteria, interstitial lobar consolidation on CXR, unexpected death from infection) documented 43 227 Multivariate analysis found four significant factors: bone marrow disease, general appearance unwell initial examination, monocyte count less than 0.1 × 109/L, peak oral equivalent temperature greater 39°C. Only contributed determining low-risk group, excluding SBI 84% se...