Effects of the kappa opioid receptor antagonist MR-2266-BS on the acquisition of ethanol preference
作者： Carmen Sandi , José Borrell , Carmen Guaza
DOI: 10.1016/0024-3205(90)90448-Z
关键词:
摘要: Using a paradigm by which rats forced to drink weak ethanol solution (2.5% w/v) (conditioning session) develop preference in consecutive retention testing days, the effects of administration kappa opioid antagonist MR-2266-BS, prior or after session, were studied. Pre-conditioning subcutaneous (s.c.) 1 mg/kg MR-2266-BS induced decrease subsequent consumption without significantly modifying acquisition preference. Post-conditioning (0.1, 1, 5 10 mg/kg) both dose-dependent reduction and throughout three following days. The results present study provide further support involvement kappa-type opioids on drinking behavior, suggest that receptors may be involved development ethanol.
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