Centrally-administered opioid selective agonists inhibit drinking in the rat.
作者： Robert L. Spencer , David Deupree , Sigmund Hsiao , Henry I. Mosberg , Victor Hruby
DOI: 10.1016/0091-3057(86)90233-9
关键词: Opioid 、 Pharmacology 、 Agonist 、 Morphine 、 Chemistry 、 κ-opioid receptor 、 Ethylketocyclazocine 、 Dynorphin 、 Potency 、 Endocrinology 、 Internal medicine 、 Enkephalin
摘要: The effects of intracerebroventricular injection mu (morphine), kappa (dynorphin-(1–13), ethylketocyclazocine, and U50,488H), delta ([D-Pen2,D-Pen5]enkephalin) opioid agonists on water intake 14 hr deprived rats was studied. All caused a dose related decrease in time spent drinking, with rank order potency dynorphin-(1–13) > morphine ethylketocyclazocine >[D-Pen2,D-Pen5]enkephalin = U50,488H. With the exception morphine, all compounds increased latency to begin but only at highest doses tested. for this endpoint [D-Pen2,D-Pen5]enkephalin U503, 488H. potent inhibition drinking following centrally-given dynorphin-(1–13), that did not affect supports role endogenous dynorphin homeostatic control balance. This function may be primarily mediated through activation receptor since 80–230 times more than selective agonist, U50,488H or ethylketocyclazocine.
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