Opioid antagonists and drinking: Evidence of κ-receptor involvement
作者： J.David Leander , Martin D. Hynes
DOI: 10.1016/0014-2999(83)90089-4
关键词:
摘要: Abstract Diprenorphine, naloxone, MR-2266-BS and WIN-44,441-3 were compared for their ability to antagonize morphine analgesia decrease deprivation-induced drinking in rats. Diprenorphine naloxone markedly more potent (32 ×) than antagonizing the analgesic effects of morphine. In contrast, diprenorphine, decreased over a similar dose range. The doses required reduce fluid consumption higher those necessary was ineffective decreasing drinking. relatively potencies suggest that effect on involves antagonist activity at κ-opioid receptor.
elsevier.com
sci-hub.se 参考文章(19)
J H Ludens, G R Slizgi, Studies on the nature and mechanism of the diuretic activity of the opioid analgesic ethylketocyclazocine. Journal of Pharmacology and Experimental Therapeutics. ,vol. 220, pp. 585- 591 ,(1982)
Tetsuo Oka, Kazuko Negishi, Mitsuaki Suda, Aiko Sawa, Masahiko Fujino, Mitsuhiro Wakimasu, Evidence that dynorphin-(1–13) acts as an agonist on opioid κ-receptors European Journal of Pharmacology. ,vol. 77, pp. 137- 141 ,(1982) , 10.1016/0014-2999(82)90008-5
R.P. Maickel, Monique C. Braude, J.E. Zabik, The effects of various narcotic agonists and antagonists on deprivation-induced fluid consumption Neuropharmacology. ,vol. 16, pp. 863- 866 ,(1977) , 10.1016/0028-3908(77)90149-6
H.W. KOSTERLITZ, S.J. PATERSON, L.E. ROBSON, CHARACTERIZATION OF THE k-SUBTYPE OF THE OPIATE RECEPTOR IN THE GUINEA-PIG BRAIN British Journal of Pharmacology. ,vol. 73, pp. 939- 949 ,(1981) , 10.1111/J.1476-5381.1981.TB08749.X
W PICKWORTH, L SHARPE, EEG-behavioral dissociation after morphine-and cyclazocine-like drugs in the dog: further evidence for two opiate receptors. Neuropharmacology. ,vol. 18, pp. 617- 622 ,(1979) , 10.1016/0028-3908(79)90114-X
Nancy L. Ostrowski, Neil Rowland, Teri L. Foley, Jeffrey L. Nelson, Larry D. Reid, Morphine antagonists and consummatory behaviors. Pharmacology, Biochemistry and Behavior. ,vol. 14, pp. 549- 559 ,(1981) , 10.1016/0091-3057(81)90316-6
S. Watson, H Akil, W Fischli, A Goldstein, E Zimmerman, G Nilaver, T. van wimersma Griedanus, Dynorphin and vasopressin: common localization in magnocellular neurons. Science. ,vol. 216, pp. 85- 87 ,(1982) , 10.1126/SCIENCE.6121376
Stephen G. Holtzman, Effects of narcotic antagonists on fluid intake in the rat. Life Sciences. ,vol. 16, pp. 1465- 1470 ,(1975) , 10.1016/0024-3205(75)90043-0
G.T. Shearman, A. Herz, Discriminative stimulus properties of bremazocine in the rat. Neuropharmacology. ,vol. 20, pp. 1209- 1213 ,(1981) , 10.1016/0028-3908(81)90066-6
John E. Morley, Allen S. Levine, Dynorphin-(1–13) induces spontaneous feeding in rats Life Sciences. ,vol. 29, pp. 1901- 1903 ,(1981) , 10.1016/0024-3205(81)90522-1