Polycrystalline-Diamond MEMS Biosensors Including Neural Microelectrode-Arrays
作者： Michael W Varney , Dean M Aslam , Abed Janoudi , Ho-Yin Chan , Donna H Wang
DOI: 10.3390/BIOS1030118
关键词:
摘要: Diamond is a material of interest due to its unique combination properties, including chemical inertness and biocompatibility. Polycrystalline diamond (poly-C) has been used in experimental biosensors that utilize electrochemical methods antigen-antibody binding for the detection biological molecules. Boron-doped poly-C electrodes have found be very advantageous applications their large potential window, low background current noise, limits (as as 500 fM). The biocompatibility comparable, or superior to, other materials commonly implants, such titanium 316 stainless steel. We developed diamond-based, neural microelectrode-array (MEA), desirability biosensor. These probes vivo electrical recording vitro detection. Poly-C activity. In studies indicate probe can detect norepinephrine at 5 nM level. propose micro-machining surface functionalization manufacturing pathogen-microsensors.
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