Correlation of clinical and in vitro erythropoietic responses to androgens in renal failure

摘要: Correlation of clinical and in vitro erythropoietic responses to androgens renal failure. To assess cultures as a tool discriminate between patients whose anemia improves with those fails improve androgens, bone marrows 24 anemic receiving maintenance hemodialysis hormonedepleted plasma clots were cultured. While erythroid colony proliferation the presence absence by cells seven good outcomes who initially studied was similar that normal donors, it reduced (P 4 at optimal erythropoietin concentrations, less than 25% enhancement growth observed only derived from nonresponder marrows. Using these criteria, nine often prospectively classified (five responders four nonresponders) identified correctly. des reponses erythropoietiques cliniques et aux androgenes dans l'insuffisance renale. Afin de determiner si les sont un outil permettant discriminer entre dont l'anemie s'ameliore ceux ne pas avec androgenes, nous avons cultive moelles osseuses malades anemiques en hemodialyse periodique du deplete hormone. Alors que la colonies erythroides l'absence ou d'androgenes partir cellules sept ayant une bonne evolution clinique etaient identiques celle donneurs normaux, elle etait reduite concentrations optimales d'erythropoietines, moins stimulation croissance par observes uniquement provenant moelle non repondeurs cliniques. En utilisant ces criteres, neuf dix prospectivement classes (cinq quatre repondeurs) ont ete correctement identifies.