Cellular distribution of hemoglobin F in a clonal hemopoietic stem-cell disorder.

摘要: Abstract Because all erythroid cells in chronic myelogenous leukemia are believed to arise from a common pluripotent stem cell, we studied the cellular distribution of fetal hemoglobin patients with disease test whether and without F have or separate stem-cell origin. In patient sickle/β thalassemia, 17 per cent red during remission 18 22 blastic phase contained hemoglobin. 24 non-hemoglobinopathic leukemic 0.3 28 F. Since erythrocytes almost exclusively derived malignant clone, these data suggest that containing originate same progenitor as those The findings argue against line "partially switched" being responsible for maintenance p...