Mammalian and Drosophila blood: JAK of all trades?

摘要: Although still in its infancy, study of Drosophila hematopoiesis shows great promise. Striking parallels with human underscore the value flies as a genetic system to gain insights into innate immune response and blood cell development. Recently, Wu Anderson 1998xWu, L.P Anderson, K.V. Nature, press. 1998; See all ReferencesWu 1998 have identified systematic screen more than 40 loci that affect immunity. Further, availability fly mutations molecules involved various signaling pathways makes powerful which characterize functional cross-talk between these pathways. Already, evidence suggests hemocyte proliferation differentiation do not depend upon same subset (Luo et al. 1997xLuo, H, Rose, P, Barber, D, Hanratty, W.P, Lee, S, Roberts, T.M, D'Andrea, A.D, Dearolf, C.R. Mol. Cell. Biol. 1997; 17: 1562–1571Crossref | PubMedSee ReferencesLuo 1997). Thus, Hop may exert effect on by activating Ras/Raf/MEK/MAPK pathway instead using STAT protein transduce signal. Possibly, hemocytes is specifically achieved through combined activation tyrosine kinase receptor (such EGFR), leading mobilization Ras pathway. In accord this model, Yamauchi 1997xYamauchi, T, Ueki, K, Tobe, Tamemoto, Sekine, N, Wada, M, Honjo, Takahashi, Hirai, H Nature. 390: 91–96Crossref PubMed Scopus (239)See ReferencesYamauchi 1997 shown mammalian JAK can phosphorylate EGFR activate Ras. Lastly, our understanding gets sophisticated, it will be interest determine whether cytokines transcription factors specify lineages also been conserved during evolution.