Anterior chamber associated immune deviation to cytosolic neural antigens avoids self-reactivity after optic nerve injury and polarizes the retinal environment to an anti-inflammatory profile.
作者： L. Martínez-Alcantar , D.K. Talavera-Carrillo , J.U. Pineda-Salazar , M. Ávalos-Viveros , G. Gutiérrez-Ospina
DOI: 10.1016/J.JNEUROIM.2019.05.005
关键词:
摘要: It has been hypothesized that anterior chamber-associated immune deviation (ACAID) to neural antigens induced prior central nervous system injury can inhibit self-reactivity and lessen secondary degeneration. This work evaluated the effect of ACAID three tissue-derived extracts (whole extract, cytosolic CE; or organelle-membrane extract) optic nerve on retinal ganglion cell (RGC) survival. The results show only CE increased RGC survival at 7 and14 days post-injury (dpi). was achieved by polarization towards an anti-inflammatory profile, driven regulatory T cells M2-type macrophages dpi.
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