MECHANISMS IN ENDOCRINOLOGY: Metabolic and inflammatory pathways on the pathogenesis of type 2 diabetes

作者: Andressa Coope , Adriana S Torsoni , Licio A Velloso

DOI: 10.1530/EJE-15-1065

关键词:

摘要: … results in an increased proportion of Prevotella, whereas Bacterioides correlates positively … mTOR in metabolic inflammation. In an experimental study, IL6 was shown to activate mTOR …

参考文章(162)
K Bendtzen, T Mandrup-Poulsen, J Nerup, J. Nielsen, C. Dinarello, M Svenson, Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans. Science. ,vol. 232, pp. 1545- 1547 ,(1986) , 10.1126/SCIENCE.3086977
Gökhan S Hotamisligil, Randall S Johnson, Robert J Distel, Ramsey Ellis, Virginia E Papaioannou, Bruce M Spiegelman, Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science. ,vol. 274, pp. 1377- 1379 ,(1996) , 10.1126/SCIENCE.274.5291.1377
Eva Tsaousidou, Lars Paeger, Bengt F. Belgardt, Martin Pal, Claudia M. Wunderlich, Hella Brönneke, Ursel Collienne, Brigitte Hampel, F. Thomas Wunderlich, Marc Schmidt-Supprian, Peter Kloppenburg, Jens C. Brüning, Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance Cell Reports. ,vol. 9, pp. 1495- 1506 ,(2014) , 10.1016/J.CELREP.2014.10.045
Susan K. Fried, Dove A. Bunkin, Andrew S. Greenberg, Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. The Journal of Clinical Endocrinology and Metabolism. ,vol. 83, pp. 847- 850 ,(1998) , 10.1210/JCEM.83.3.4660
Marc L. Reitman, Eric E. Schadt, Pharmacogenetics of metformin response: a step in the path toward personalized medicine. Journal of Clinical Investigation. ,vol. 117, pp. 1226- 1229 ,(2007) , 10.1172/JCI32133
Vivian C Calegari, Adriana S Torsoni, Emerielle C Vanzela, Eliana P Araújo, Joseane Morari, Claudio C Zoppi, Lourenço Sbragia, Antonio C Boschero, Lício A Velloso, None, Inflammation of the Hypothalamus Leads to Defective Pancreatic Islet Function Journal of Biological Chemistry. ,vol. 286, pp. 12870- 12880 ,(2011) , 10.1074/JBC.M110.173021
M. Milanski, G. Degasperi, A. Coope, J. Morari, R. Denis, D. E. Cintra, D. M. L. Tsukumo, G. Anhe, M. E. Amaral, H. K. Takahashi, R. Curi, H. C. Oliveira, J. B. C. Carvalheira, S. Bordin, M. J. Saad, L. A. Velloso, Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. The Journal of Neuroscience. ,vol. 29, pp. 359- 370 ,(2009) , 10.1523/JNEUROSCI.2760-08.2009
Katharina Brandl, Thomas Glück, Pia Hartmann, Bernd Salzberger, Werner Falk, A designed TLR4/MD-2 complex to capture LPS. Journal of Endotoxin Research. ,vol. 11, pp. 197- 206 ,(2005) , 10.1177/09680519050110040301
J. Stoy, E. L. Edghill, S. E. Flanagan, H. Ye, V. P. Paz, A. Pluzhnikov, J. E. Below, M. G. Hayes, N. J. Cox, G. M. Lipkind, R. B. Lipton, S. A. W. Greeley, A.-M. Patch, S. Ellard, D. F. Steiner, A. T. Hattersley, L. H. Philipson, G. I. Bell, , Insulin gene mutations as a cause of permanent neonatal diabetes Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 15040- 15044 ,(2007) , 10.1073/PNAS.0707291104
Julie Hollien, Evolution of the unfolded protein response. Biochimica et Biophysica Acta. ,vol. 1833, pp. 2458- 2463 ,(2013) , 10.1016/J.BBAMCR.2013.01.016