Molecular markers for colon diagnosis, prognosis and targeted therapy.
作者： Daniel O. Herzig , Vassiliki L. Tsikitis
DOI: 10.1002/JSO.23806
关键词:
摘要: Colorectal adenocarcinoma (CRC), the second leading cancer-related death in United States, remains a global public health issue. Sporadic CRC is considered result of sequential mucosal changes from normal colonic mucosa to adenocarcinoma. Efforts understanding molecular pathways tumorigenesis may lead identifying novel, individually tailored therapeutic targets for patients. In this review, we focus on well-published prognostic and predictive markers examine their role clinical practice.
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sci-hub.se 参考文章(79)
Adriaan de Bruïne, Anton de Goeij, Joop ten Kate, Marjolein van Driel, Peter Moerkerk, Jan Willem Arends, Type and Number of Ki-ras Point Mutations Relate to Stage of Human Colorectal Cancer Cancer Research. ,vol. 54, pp. 3376- 3378 ,(1994)
Timothy S. Lewis, Paul S. Shapiro, Natalie G. Ahn, Signal Transduction through MAP Kinase Cascades Advances in Cancer Research. ,vol. 74, pp. 49- 139 ,(1998) , 10.1016/S0065-230X(08)60765-4
Alex Duval, Richard Hamelin, Mutations at Coding Repeat Sequences in Mismatch Repair-deficient Human Cancers Toward a New Concept of Target Genes for Instability Cancer Research. ,vol. 62, pp. 2447- 2454 ,(2002)
Yohko Hikiba, Tsuneo Ikenoue, Hideaki Ijichi, Jun Aragaki, Keisuke Tateishi, Fumihiko Kanai, Takao Kawabe, Takaaki Imamura, Jun Imamura, Takayuki Kawakami, Miki Ohta, Yasuo Tanaka, Masayuki Matsumura, Masao Omata, Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors. Cancer Research. ,vol. 63, pp. 8132- 8137 ,(2003)
Yosef Yarden, Mark X. Sliwkowski, Untangling the ErbB signalling network Nature Reviews Molecular Cell Biology. ,vol. 2, pp. 127- 137 ,(2001) , 10.1038/35052073
Miriam Koopman, Sabine Venderbosch, Harm van Tinteren, Marjolijn J. Ligtenberg, Iris Nagtegaal, Johan H. Van Krieken, Cornelis J. Punt, Predictive and prognostic markers for the outcome of chemotherapy in advanced colorectal cancer, a retrospective analysis of the phase III randomised CAIRO study. European Journal of Cancer. ,vol. 45, pp. 1999- 2006 ,(2009) , 10.1016/J.EJCA.2009.04.017
K Jin Kim, Bing Li, Jane Winer, Mark Armanini, Nancy Gillett, Heidi S Phillips, Napoleone Ferrara, None, Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo Nature. ,vol. 362, pp. 841- 844 ,(1993) , 10.1038/362841A0
A J Munro, S Lain, D P Lane, P53 abnormalities and outcomes in colorectal cancer: a systematic review British Journal of Cancer. ,vol. 92, pp. 434- 444 ,(2005) , 10.1038/SJ.BJC.6602358
S. Olschwang, R. Hamelin, P. Laurent-Puig, B. Thuille, Y. De Rycke, Y.-J. Li, F. Muzeau, J. Girodet, R.-J. Salmon, G. Thomas, Alternative genetic pathways in colorectal carcinogenesis Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 12122- 12127 ,(1997) , 10.1073/PNAS.94.22.12122
Harith Rajagopalan, Alberto Bardelli, Christoph Lengauer, Kenneth W. Kinzler, Bert Vogelstein, Victor E. Velculescu, Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature. ,vol. 418, pp. 934- 934 ,(2002) , 10.1038/418934A