Type and Number of Ki-ras Point Mutations Relate to Stage of Human Colorectal Cancer

摘要: Point mutations in the Ki- ras gene belong to genetic key events tumorigenesis of colorectal cancer. The type and number point were detected specimens from patients with carcinomas staged as Dukes B C using single-stranded conformational polymorphism analysis sequencing. G-A transitions codon 12 exclusively found tumors, G-T transversions mainly C, G-C only tumors. Apparently, are associated metastatic behavior carcinomas, while not. In several samples, multiple could be 12, frequency increasing stage tumor.