SNHG15 knockdown inhibits diabetic nephropathy progression in pediatric patients by regulating the miR-141/ICAM-1 axis in vitro.
作者： Tana Zhao , Ying Wang , Jiewei Liu , Yanhong Zou , Dongliang Cai
DOI: 10.1042/BSR20204099
关键词:
摘要: Long non-coding RNAs (lncRNAs) are confirmed to be involved in modulating diabetic nephropathy (DN). The present study is aimed explore the regulatory mechanism of lncRNA small nucleolar RNA host gene 15 (SNHG15) on pediatric DN. Human glomerular mesangial cells (HGMCs) were exposed high glucose (HG) produce an vitro model. results showed that SNHG15 was remarkably up-regulated DN tissues and HG-induced HGMCs. Functional experiments indicated both silencing overexpression miR-141 elevated cell viability, suppressed inflammation identified a could bind miR-141, ICAM-1 downstream target miR-141. Both low expression reversed inhibiting effect knockdown inflammatory response, promoting viability. To conclude, our revealed ameliorated malignant behaviors via miR-141/ICAM-1 axis vitro.
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