作者: F. Laurent , R. Gross , M. Lakili , P. Mialhe
DOI: 10.1007/BF00253821
关键词:
摘要: A possible action of insulin via glucose metabolism on the pancreatic cell response to glucose, was studied in ducks. 2-Deoxyglucose, a non metabolizable analogue used. In normal ducks, hyperglycaemia induced by 2-deoxyglucose (IV: 0.5g/kg) resulted hyper glucagonaemia, while same degree glycaemia, infusion (IV injection 25 mg/kg, and 5 mg/kg/min) immediately suppressed glucagon secretion. diabetic two days after subtotal pancreatectomy, responsiveness abolished, but could be restored treatment before (IM 0.2 U/kg + 8 μg/kg every 6 h) during 3.6 mU/kg 0.9 mU/kg/min) test 0.5 g /kg). The not observed insulintreated ducks administration g/kg). These data suggest an inhibitory effect release glucagon. addition, may mediated its within cell.