Effect of insulin on glucagon secretion mediated via glucose metabolism of pancreatic A cells in ducks.

作者: F. Laurent , R. Gross , M. Lakili , P. Mialhe

DOI: 10.1007/BF00253821

关键词:

摘要: A possible action of insulin via glucose metabolism on the pancreatic cell response to glucose, was studied in ducks. 2-Deoxyglucose, a non metabolizable analogue used. In normal ducks, hyperglycaemia induced by 2-deoxyglucose (IV: 0.5g/kg) resulted hyper glucagonaemia, while same degree glycaemia, infusion (IV injection 25 mg/kg, and 5 mg/kg/min) immediately suppressed glucagon secretion. diabetic two days after subtotal pancreatectomy, responsiveness abolished, but could be restored treatment before (IM 0.2 U/kg + 8 μg/kg every 6 h) during 3.6 mU/kg 0.9 mU/kg/min) test 0.5 g /kg). The not observed insulintreated ducks administration g/kg). These data suggest an inhibitory effect release glucagon. addition, may mediated its within cell.

参考文章(27)
P. Mialhe, THE ROLE OF GLUCAGON IN BIRDS AND MAMMALS The Evolution of Pancreatic Islets#R##N#Proceedings of a Symposium Held at Leningrad, September 1975, under the Auspices of the Academy of Sciences, Leningrad. pp. 291- 300 ,(1976) , 10.1016/B978-0-08-021257-9.50027-9
C.-G. Östenson, A. Andersson, S. E. Brolin, B. Petersson, C. Hellerström, Effects of Insulin on the Glucagon Release, Glucose Utilization and ATP Content of the Pancreatic A Cells of the Guinea Pig GLUCAGON: Its Role in Physiology and Clinical Medicine. pp. 243- 254 ,(1977) , 10.1007/978-1-4612-6366-1_18
Arne Andersson, Carl-Gustaf Groth, Rolf Gunnarsson, Claes Hellerström, Göran Lundgren, Birger Petersson, Jan Östman, METABOLIC AND SECRETORY CHARACTERISTICS OF CULTURED HUMAN ISLETS OF LANGERHANS Regulatory Mechanisms of Carbohydrate Metabolism#R##N#11th Meeting Copenhagen 1977. pp. 249- 257 ,(1978) , 10.1016/B978-0-08-022623-1.50028-9
Arne N. Wick, Douglas R. Drury, Henry I. Nakada, Jack B. Wolfe, Barbara Britton, Ruth Grabowski, LOCALIZATION OF THE PRIMARY METABOLIC BLOCK PRODUCED BY 2-DEOXYGLUCOSE Journal of Biological Chemistry. ,vol. 224, pp. 963- 969 ,(1957) , 10.1016/S0021-9258(18)64988-9
William S. Hoffman, A RAPID PHOTOELECTRIC METHOD FOR THE DETERMINATION OF GLUCOSE IN BLOOD AND URINE Journal of Biological Chemistry. ,vol. 120, pp. 51- 55 ,(1937) , 10.1016/S0021-9258(18)74360-3
Walter A. Müller, Gerald R. Faloona, Roger H. Unger, The effect of experimental insulin deficiency on glucagon secretion Journal of Clinical Investigation. ,vol. 50, pp. 1992- 1999 ,(1971) , 10.1172/JCI106691
B. A. Larson, T. L. Williams, M. O. Showers, W. P. VanderLaan, Effect of 2-deoxyglucose on [32P] phosphate and insulin release from perifused rat pancreatic islets. Diabetologia. ,vol. 17, pp. 117- 120 ,(1979) , 10.1007/BF01222212
A S Pagliara, S N Stillings, M W Haymond, B A Hover, F M Matschinsky, Insulin and glucose as modulators of the amino acid-induced glucagon release in the isolated pancreas of alloxan and streptozotocin diabetic rats. Journal of Clinical Investigation. ,vol. 55, pp. 244- 255 ,(1975) , 10.1172/JCI107928