METABOLIC AND SECRETORY CHARACTERISTICS OF CULTURED HUMAN ISLETS OF LANGERHANS
作者： Arne Andersson , Carl-Gustaf Groth , Rolf Gunnarsson , Claes Hellerström , Göran Lundgren
DOI: 10.1016/B978-0-08-022623-1.50028-9
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摘要: Publisher Summary This chapter elaborates the metabolic and secretory characteristics of cultured human islets Langerhans. The oxygen consumption incubated in diver experiments after 7 days culture remained linear for 2h. It is shown that rate up take increased by addition glucose to medium. observed increase 23% respiratory rat eat higher concentration was significant. appears from present observations on respiration together with previous ultrastructural studies excellent viability maintained throughout period. further supported significant stimulation uptake high concentration, which one others have be a characteristic property islet cells several experimental animals. proportion A 2-cells might explain less pronounced stimulatory action glucose. found 2-cell poorly stimulated
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