PADI4 acts as a coactivator of Tal1 by counteracting repressive histone arginine methylation.

摘要: The transcription factor Tal1 is a critical activator or repressor of gene expression in hematopoiesis and leukaemia. mechanism by which differentially influences distinct genes not fully understood. Here we show that interacts with the peptidylarginine deiminase IV (PADI4). We demonstrate PADI4 can act as an epigenetic coactivator through influencing H3R2me2a. At Tal1/PADI4 target IL6ST repressive H3R2me2a mark triggered PRMT6 counteracted PADI4, augments active H3K4me3 thus increases expression. In contrast, at CTCF promoter acts repressor. propose influence on plays role control during lineage differentiation hematopoietic stem/progenitor cells. These results open possibility to pharmacologically