Efficacy and Safety of Combination Acitretin and Pioglitazone Therapy in Patients With Moderate to Severe Chronic Plaque-Type Psoriasis

摘要: Objective To evaluate the efficacy and safety of combination therapy with acitretin pioglitazone hydrochloride in patients moderate to severe chronic plaque-type psoriasis. Design Randomized, double-blind, placebo-controlled clinical trial. Setting A tertiary care referral hospital. Patients The study included either sex (age range, 18-65 years) were excluded if they child-bearing potential or had impaired liver renal function, hyperlipidemia, diabetes mellitus, coronary artery disease, a body mass index greater than 30 (calculated as weight kilograms divided by height meters squared). Of 62 screened, 41 randomly assigned 2 groups: 22 an (25 mg) plus placebo group 19 (15 group. Main Outcome Measure Change Psoriasis Area Severity Index score between groups from baseline 12 weeks. Results After weeks therapy, percentage reduction was 64.2% 51.7% majority adverse events mild except for 1 possibly unrelated episode acute myocardial infarction 49-year-old woman Conclusions Pioglitazone has beneficial antipsoriatic effect may provide convenient, efficacious, relatively safe option combine acitretin, although further studies are needed. Trial Registration clinicaltrials.gov Identifier:NCT00395941