Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster

摘要: Loss of cell polarity and cancer are tightly correlated1, but proof for a causative relationship has remained elusive. In stem cells, loss impairment asymmetric division could alter fates thereby render daughter cells unable to respond the mechanisms that control proliferation2. To test this hypothesis, we generated Drosophila melanogaster larval neuroblasts containing mutations in various genes then assayed their proliferative potential after transplantation into adult hosts. We found brain tissue carrying with raps (also called pins), mira, numb or pros grew more than 100 times initial size, invading other tissues killing hosts 2 weeks. These tumors became immortal be retransplanted new years. Six weeks first implantation, genome instability centrosome alterations, two traits malignant carcinomas3,4, appeared these tumors. Increasing evidence suggests some may origin5,6. Our results show function any several fate cell's daughters result hyperproliferation, triggering chain events subverts homeostasis general sense leads cancer.