FIV infection induces unique changes in phenotype and cellularity in the medial iliac lymph node and intestinal IEL.
作者： Kristina E. Howard , Mary Jo Burkhard
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摘要: Studies of human immunodeficiency virus-1 (HIV-1)-infected patients and simian virus (SIV)-infected macaques have identified profound depletion CD4+ T cells expansion CD8+ in the gastrointestinal lamina propria. Less attention has been given to intraepithelial lymphocytes (IEL), no studies concurrently examined inductive sites such as draining lymph nodes. Our preliminary data feline (FIV) animal model suggested additional changes IEL, marked differences responses nodes different mucosal sites. To address this, we quantified absolute leukocyte yield phenotype from small intestinal mesenteric node (MLN), medial iliac (ILN) chronically FIV-infected cats. The cellularity ILN was increased 530% animals with an CD62L+ cells, suggesting population naive cells. number CD4+, well a...
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