Altered Glucoregulatory Response to Physiological Infusions of Epinephrine and Glucagon in Hyperthyroidism

摘要: To study the mechanism of altered glucose homeostasis in hyperthyroidism, effects a 2-h physiological infusion epinephrine (0.05 μg%kg-min) or glucagon (3 ng%kgmin) on kinetics and glucoregulatory hormones were determined nine normal subjects five untreated hyperthyroid patients. Under basal conditions, patients exhibited increased turnover (2.2 ± 0.09 us. 1.62 ±0.1 mg%kg-min normals), modest hyperglycemia, hyperglucagonemia, levels plasma insulin, cortisol, GH. In subjects, induced sustained increase (45 mg/dl), reflecting transient 100% rise output, 28% decrease clearance. patients, was significantly lower (22 mg/dl) due to smaller but output (45%) lack fall Plasma insulin rose peak 80% higher than baseline whereas n...