The serum from dialysis patients with acute coronary syndrome up-regulates the expression of TLR2 and its downstream effectors in human renal glomerular endothelial cells.
作者： Xianglei Kong , Jing Sun , Meiyu Cui , Dongmei Xu
DOI: 10.3109/0886022X.2014.886466
关键词:
摘要: AbstractBackground: This study was to investigate the expression of toll-like receptor 2 and its downstream effectors in endothelial cells response serum from maintenance hemodialysis (MHD) patients with acute coronary syndrome (ACS). Methods: Human renal glomerular (HRGEC) were treated vitro healthy subjects (control group), MHD stable angina pectoris (SAP or ACS (ACS group). The group cultured presence absence TLR2 signaling blockers for 18 h. mRNA level TLR2, nuclear factor-κB (NF-κB), interleukin-6 (IL-6) vascular cell adhesion molecule-1 (VCAM-1) examined by real-time qPCR, localization detected immunocytochemistry, secretion IL-6 VCAM-1 measured enzyme-linked immunosorbent assay. Results: NF-κB statistically higher when compared those SAP hea...
informahealthcare.com参考文章(23)
S. Pagano, N. Satta, D. Werling, V. Offord, P. de Moerloose, E. Charbonney, D. Hochstrasser, P. Roux-Lombard, N. Vuilleumier, Anti-apolipoprotein A-1 IgG in patients with myocardial infarction promotes inflammation through TLR2/CD14 complex. Journal of Internal Medicine. ,vol. 272, pp. 344- 357 ,(2012) , 10.1111/J.1365-2796.2012.02530.X
Jean-Eric Alard, Fanny Gaillard, Capucine Daridon, Yehuda Shoenfeld, Christophe Jamin, Pierre Youinou, TLR2 Is One of the Endothelial Receptors for β2-Glycoprotein I Journal of Immunology. ,vol. 185, pp. 1550- 1557 ,(2010) , 10.4049/JIMMUNOL.1000526
Adam E Mullick, Peter S Tobias, Linda K Curtiss, Modulation of atherosclerosis in mice by Toll-like receptor 2 Journal of Clinical Investigation. ,vol. 115, pp. 3149- 3156 ,(2005) , 10.1172/JCI25482
Filippo Crea, Giovanna Liuzzo, Pathogenesis of Acute Coronary Syndromes Journal of the American College of Cardiology. ,vol. 61, pp. 1- 11 ,(2013) , 10.1016/J.JACC.2012.07.064
So Kuwahata, Shoji Fujita, Koji Orihara, Shuichi Hamasaki, Ryutaro Oba, Hiroyuki Hirai, Kinya Nagata, Sanemasa Ishida, Tetsuro Kataoka, Naoya Oketani, Hitoshi Ichiki, Yasuhisa Iriki, Keishi Saihara, Hideki Okui, Yuichi Ninomiya, Chuwa Tei, None, High expression level of Toll-like receptor 2 on monocytes is an important risk factor for arteriosclerotic disease. Atherosclerosis. ,vol. 209, pp. 248- 254 ,(2010) , 10.1016/J.ATHEROSCLEROSIS.2009.08.046
Bart Legein, Lieve Temmerman, Erik A. L. Biessen, Esther Lutgens, Inflammation and immune system interactions in atherosclerosis. Cellular and Molecular Life Sciences. ,vol. 70, pp. 3847- 3869 ,(2013) , 10.1007/S00018-013-1289-1
Robert Toto, David Windus, Daniel Ornt, Andrew S. Levey, for the Hemo Study Group, Alfred K. Cheung, Mark J. Sarnak, Guofen Yan, Michael Berkoben, Robert Heyka, Allen Kaufman, Julia Lewis, Michael Rocco, Cardiac diseases in maintenance hemodialysis patients: results of the HEMO Study. Kidney International. ,vol. 65, pp. 2380- 2389 ,(2004) , 10.1111/J.1523-1755.2004.00657.X
Ryuichiro Fukushima, Hirofumi Soejima, Takashi Fukunaga, Masafumi Nakayama, Yoko Oe, Shuichi Oshima, Seigo Sugiyama, Hisao Ogawa, Expression levels of Toll-like receptor genes in coronary atherosclerotic lesions of patients with acute coronary syndrome or stable angina pectoris. Circulation. ,vol. 73, pp. 1479- 1484 ,(2009) , 10.1253/CIRCJ.CJ-08-1146
Ying-ying Chen, Jie Chen, Jian-wei Hu, Zi-li Yang, Yue-liang Shen, Enhancement of lipopolysaccharide-induced toll-like receptor 2 expression and inflammatory cytokine secretion in HUVECs under high glucose conditions Life Sciences. ,vol. 92, pp. 582- 588 ,(2013) , 10.1016/J.LFS.2013.01.021
Wei Chao, Yan Shen, Xinsheng Zhu, Huailong Zhao, Mikhail Novikov, Ulrich Schmidt, Anthony Rosenzweig, Lipopolysaccharide improves cardiomyocyte survival and function after serum deprivation. Journal of Biological Chemistry. ,vol. 280, pp. 21997- 22005 ,(2005) , 10.1074/JBC.M413676200