Drug Repurposing for Schistosomiasis: Combinations of Drugs or Biomolecules

摘要: Schistosomiasis is a major neglected tropical disease. Control of schistosomiasis currently relies on single drug, praziquantel, and despite its efficacy against the all schistosome species that parasitize humans, it displays some problematic drawbacks alone ineffective in counteracting adverse pathologies associated with infection. Moreover, due to development potential emergence PZQ-resistant strains, search for additional or alternative antischistosomal drugs have become public health priority. The current drug discovery has been slow uninspiring. By contrast, repurposing existing approved may offer safe, rapid cost-effective alternative. Combined treatment PZQ other different mode action, i.e., antimalarials, shows promise results. In addition, combination anthelminthic antioxidant might be advantageous modulating oxidative processes schistosomiasis. Herein, we review studies dealing therapies involve and/or agents Whereas combined not interfere efficacy, combinations nonetheless ameliorate tissue damage infection-associated complications. fact, combine drugs, antioxidants valuable adjuvant reduce morbidity mortality Therefore, attempting new anthelmintic biomolecules such as provides avenues alternatives PZQ.