Preoperative pelvic radiation increases the risk for ileal pouch failure in patients with colitis-associated colorectal cancer☆☆☆

摘要: Abstract Background and aims To evaluate the impact of preoperative radiation on pouch outcomes in patients with colitis-associated cancer (CAC). Methods CAC who underwent restorative proctocolectomy ileal pouch-anal anastomosis (IPAA) from 1984 to 2009 were identified our registry. The pelvic for or other related was evaluated. Results Sixty-three confirmed included (37 male, 58.7%). mean age at construction 46.9 ± 10.6 years. Seven excluded due presence persistent diverting ileostomy (n = 2) no follow-up (n = 5). remaining 56 analyzed, including 9 received prior IPAA creation CRC cancers. Preoperative significantly associated chronic pouchitis (P = 0.024). There was, however, correlation between pouch/anal transitional zone neoplasia, stricture, abscess fistula/sinus. Pouch failure occurred 13 after a median 66.4 (range: 2.7–322.2) months. Although simple statistical analysis based number did not achieve significance (4/9 vs. 9/47, P = 0.19), Kaplan–Meier showed strong association risk (P  Conclusions Pelvic administered appears be poor outcomes. Oncological benefits functional should carefully balanced before is considered proctocolectomy.