Evaluating the anticancer activity and nanoparticulate nature of homeopathic preparations of Terminalia chebula.

摘要: Background Breast cancer is the most common diagnosed among women and second leading cause of death. Homeopathic medicines are part alternative that given as a supportive therapy in breast cancer. The objective this study was to investigate anticancer activity commercially available homeopathic preparations Terminalia chebula (TC) evaluate their nanoparticulate nature. Methods Mother tincture (MT) other (3X, 6C and 30C) TC were tested for effect on viability (MDAMB231 MCF7) non-cancerous (HEK 293) cell lines by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell growth assay performed analyze different potencies kinetics cells. MT 6C evaluated presence nanoparticles using scanning electron microscopy (SEM) transmission (TEM). Results decreased However, only cells without affecting All potencies, MT, 3X, 30C, reduced cells, more specifically at 1:10 dilution 24, 48 72 h. Under SEM, appeared mesh-like structure whereas under TEM, it showed nanoclusters. On hand, potency contained 20 nm sized nanoparticles. Conclusion current reports against reveals These preliminary results warrant further mechanistic studies both in vitro in vivo levels potential nanomedicine