Prolymphocytic Leukemia: Malignancy of Activated B Cells with an Apoptosis-like Response to Anti-Human IgM Signal Transduction

摘要: B-prolymphocytic leukemia (PLL) resembles B-chronic lymphocytic (CLL) in the expression of surface IgM, but differs morphology, cellular function, and clinical features, suggesting that PLL CLL may be derived from distinct B cell subsets ontogeny. In studies signaling effect anti-human IgM (anti-μ) on malignancies, divalent F(ab') anti-μ neither stimulated nor inhibited DNA synthesis cells exerted a unique negative direct cytotoxicity complement-free cultures with morphological changes characteristic “programmed death” mechanism or apoptosis. The susceptibility to anti-μ-triggered is similar observed “tolerogenic” normal cells. findings activated phenotypes PLL, high level autonomous activity large “transformed” cells, mitogen-induced transformation indicate PLL...