Growth arrest specific transcript 5 in tumorigenesis process: An update on the expression pattern and genomic variants.
作者： Soudeh Ghaforui-Fard , Mohammad Taheri
DOI: 10.1016/J.BIOPHA.2019.108723
关键词:
摘要: Growth arrest-specific 5 (GAS5) is a long non-coding RNA (lncRNA) with diverse functions in regulation of gene expression. Most studies have reported role for this lncRNA induction cell apoptosis and suppression tumorigenesis process. Although few demonstrated up-regulation tumor tissues compared to non-tumor the same origin, results vitro functional mostly support suppressor GAS5. A number recent also shown associations between genomic variants risk cancer some populations. The modulation response anti-cancer regimens has been verified through both clinical studies. Taken together, putative biomarker therapeutic target human malignancies.
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